Stable long-term functional connectivity predict multiple aspects of cortico-cortical evoked potentials

Abstract Direct cortical stimulation holds the potential to treat a range of neuropsychiatric disorders in which connectivity distributed networks functions abnormally. Mapping cortico-cortical evoked potentials (CCEPs) response direct electrical brain provides powerful insight into organization networks. Despite many advances quantifying with CCEPs, timing, direction, and magnitude responses are not fully understood. To better elucidate relationship between CCEPs networks, we collected human electrocorticographic recordings from neurosurgical epilepsy patients while delivering single pulses stimulation. We then created directed adjacency matrix based on electrodes responded. Next, built functional matrices at-rest data at least 12 hours separated session. demonstrate that estimated connections significantly overlap vice versa. Notably, one technique used generate was able capture directionality another predicted onset CCEPs. Using different metrics predict is impactful as it new insights tools for analyzing These results will enable more precise predictions furthering development targeted therapies. Research Category Technology Methods Clinical Research: 13. Other Brain Stimulation Keywords: Cortical stimulation, Cortico-cortical potentials, Functional connectivity,